Charles Perkins Centre and the School of Molecular Bioscience, The University of Sydney, Sydney, Australia Joslin Diabetes Center, Boston, MA. Department of Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, Newcastle, Australia Hunter Medical Research Institute, School of Medicine and Public Health, University of Newcastle, Rankin Park, Australia. Children's Hospital, Boston, MA Harvard Medical School, Boston, MA. Charles Perkins Centre and the School of Molecular Bioscience, The University of Sydney, Sydney, Australia. Joslin Diabetes Center, Boston, MA Harvard Medical School, Boston, MA howard.wolpert@joslin.harvard.edu.